Michael Thomas - WR - New Orleans Saints
New Orleans Saints WR Michael Thomas (illness) fully participated in practice Friday, Sept. 14, and is not on the injury report for Week 2.
Huddle Up: Thomas continues to be one of the most valuable fantasy receivers in the NFL and will be a weekly No. 1 receiver in all leagues as long as he is healthy.
Jarvis Landry - WR - Cleveland Browns
Cleveland Browns WR Jarvis Landry (thigh) fully participated in practice Friday, Sept. 14, and is not on the injury report for Week 2.
Huddle Up: Landry was targeted 15 times in Week 1 and should continue to be a reliable option in the Browns passing game. He will have a favorable matchup this week and can be a No. 2 or No. 3 receiver in all leagues.
Dak Prescott - QB - Dallas Cowboys
Dallas Cowboys QB Dak Prescott (ankle) fully participated in practice Friday, Sept. 14, and is not on the injury report for Week 2.
Huddle Up: Prescott did not play well in Week 1 and appears to be trying to build chemistry with his new pass catchers. He likely will have a better game against the New York Giants but probably should be benched until he can have consecutive strong performances.
Sterling Shepard - WR - New York Giants
New York Giants WR Sterling Shepard (back) fully participated in practice Friday, Sept. 14, and is not on the injury report for Week 2.
Huddle Up: Shepard is coming off a decent outing in Week 1 and was targeted seven times during that game. He could have some success against the Dallas Cowboys this week and has a chance to be a flex option in deeper leagues.
DeSean Jackson - WR - Tampa Bay Buccaneers
Updating a previous report, Tampa Bay Buccaneers WR DeSean Jackson (concussion, shoulder) fully participated in practice Friday, Sept. 14, but is listed as questionable for Week 2.
Huddle Up: Jackson may be a game-time decision for Week 2, so owners will need to keep an eye on the situation over the next few days. He was able to post terrific numbers last week and would be a deep threat again this week if he is cleared. He can be at least a No. 3 receiver if he plays.
Ryan Grant - WR - Indianapolis Colts
Indianapolis Colts WR Ryan Grant (chest) fully participated in practice Friday, Sept. 14, and is not on the injury report for Week 2.
Huddle Up: Grant is coming off a productive Week 1 performance and should continue to be a solid option in the Colts passing game. He can be at least a flex option in some leagues and could even be a No. 3 receiver in some deeper leagues.
Marlon Mack - RB - Indianapolis Colts
Indianapolis Colts RB Marlon Mack (hamstring) fully participated in practice Friday, Sept. 14, but is listed as questionable for Week 2.
Huddle Up: Mack appears to have a good chance to play this week, but owners will need to check the inactive list to see if he will be in uniform. He may split playing time with Jordan Wilkins and Nyheim Hines, which would hurt his value. Owners could consider Mack as a flex option in some leagues, but he could also be benched depending on other options available.
Blaine Gabbert - QB - Tennessee Titans
Tennessee Titans QBs Marcus Mariota (elbow) and Blaine Gabbert are both expected to see playing time in Week 2 against the Houston Texans, according to head coach Mike Vrabel.
Huddle Up: This feels like a very Bill Belichick kind of move from the former New England Patriot player, but the likelihood is that if Mariota is healthy enough to play and starts out well, he will probably play most of the game. A bigger problem for whichever quarterback is playing this week will be the absence of both of his starting tackles against the Texans' lethal pass-rushing group led by J.J. Watt, Jadeveon Clowney and Whitney Mercilus. Needless to say, Mariota and Gabbert can be avoided in fantasy this week.
Alshon Jeffery - WR - Philadelphia Eagles
Philadelphia Eagles WR Alshon Jeffery (shoulder) was limited during practice Friday, Sept. 14, and has been ruled out for Week 2.
Huddle Up: Jeffery will not play this week but should have a decent chance to play in Week 3. Nelson Agholor should continue to serve as the top receiver for the Eagles and can be a No. 3 fantasy receiver in most leagues.
Cameron Meredith - WR - New Orleans Saints
New Orleans Saints WR Cameron Meredith is still 'getting up to speed' in the offense, according to head coach Sean Payton.
Huddle Up: Meredith was unable to participate much during the offseason program or the preseason due to injury, so it wouldn't be a surprise if he was a game-day inactive for at least another week or two. Payton made it clear during the summer he had a plan in place about how he wanted to use Meredith, so owners should keep him stashed if at all possible and near the top of their watch lists if they can't. He should have WR3 upside when he's ready.
Calvin Ridley - WR - Atlanta Falcons
Atlanta Falcons WR Calvin Ridley is expected to be more involved in the game plan moving forward, according to head coach Dan Quinn. Ridley was held without a catch on two targets in Week 1 against the Philadelphia Eagles.
Huddle Up: A slow start should have been expected for Ridley, as Julio Jones is the centerpiece of the offense and Mohamed Sanu is a trusted and steady veteran receiver. The rookie will undoubtedly endear himself to Matt Ryan as the season progresses given how advanced he already is as a route-runner. He should be stashed in deeper leagues and remain on watch lists in leagues with shallow rosters.
Darren Sproles - RB - Philadelphia Eagles
Philadelphia Eagles RB Darren Sproles (hamstring) on Friday, Sept. 14, was ruled out for the Week 2 game against the Tampa Bay Buccaneers.
Huddle Up: Sproles was second among Philly RBs with nine touches in the Week 1 win over the Falcons, and while Jay Ajayi remains the team's primary back, Corey Clement now receives a bump up into fantasy flex territory with Sproles out.
Devonta Freeman - RB - Atlanta Falcons
Updating a previous report, Atlanta Falcons RB Devonta Freeman (knee) on Friday, Sept. 14, was ruled out of Sunday's Week 2 game against the Carolina Panthers. Head coach Dan Quinn said there is nothing structurally wrong with Freeman's knee and hopes it is not a long-term injury.
Huddle Up: Tevin Coleman is now up as the main man in the Falcons' backfield and is a solid RB2 start Sunday. Rookie Ito Smith will be the No. 2 back but is not expected to see enough touches to be useful in the majority of leagues.
Ben Roethlisberger - QB - Pittsburgh Steelers
Pittsburgh Steelers QB Ben Roethlisberger (elbow) was a full participant in practice Friday, Sept. 14, according to head coach Mike Tomlin.
Huddle Up: Week 1 in rainy Cleveland was a struggle for Big Ben (one TD, five turnovers), but big things are expected Sunday as he's back home for a favorable matchup against the Kansas City Chiefs. Start him with confidence.
Jermaine Kearse - WR - New York Jets
New York Jets WR Jermaine Kearse (abdomen) is expected to play in the Week 2 game against the Miami Dolphins on Sunday, Sept. 16.
Huddle Up: Kearse is set to make his 2018 debut, but not much can be expected fantasy-wise as WRs Robby Anderson, Quincy Enunwa and Terrelle Pryor are all better options in a low-volume N.Y. passing game with rookie QB Sam Darnold at the helm.
Rex Burkhead - RB - New England Patriots
New England Patriots RB Rex Burkhead (concussion) participated in his second straight day of practice Friday, Sept. 14.
Huddle Up: Burkhead, of course, still has to clear the concussion protocol, and even if so, he also could be competing with the likes of James White and rookie Sony Michel for touches Sunday in a tough matchup with the Jacksonville Jaguars. That said, he's a solid flex option if active.
Jerick McKinnon - RB - San Francisco 49ers
San Francisco 49ers RB Jerick McKinnon (knee) underwent right knee surgery to repair a torn ACL on Tuesday, Sept. 11.
Huddle Up: McKinnon was informed the tear was "clean," which is the best news he could have received given the fact he suffered a season-ending injury. Because the tear was clean and no other ligaments were damaged, he should be ready to participate in offseason activities and certainly be cleared for training camp if he does not encounter a setback.
DeSean Jackson - WR - Tampa Bay Buccaneers
Tampa Bay Buccaneers WR DeSean Jackson (concussion) practiced Friday, Sept. 14, but head coach Dirk Koetter did not say if Jackson has cleared the league's concussion protocol.
Huddle Up: Jackson still has two days to gain clearance, and if so, he's a flex option coming off his monster Week 1 showing in the Big Easy.
Dak Prescott - QB - Dallas Cowboys
Dallas Cowboys QB Dak Prescott (ankle) has the backing of team owner Jerry Jones. 'I have tremendous confidence in Dak,' Jones said Friday, Sept. 14, in an interview on Dallas radio station 105.3 The Fan. 'I feel so good about Sunday. I feel good about our future. I don't want to be trite, but teams have lost games and have had bad games with the best quarterbacks there's ever been. I'm talking about generally speaking. You can have an outing that you'd like to have back, but man alive, one of the strengths of our team going in against the Giants or one of the strengths of our team as far as I can see into the future is Dak Prescott.'
Huddle Up: After a disappointing finish last season, Prescott is off to a shaky start in 2018, completing 19-of-29 passes for 170 yards and no TDs in a 16-8 Week 1 loss to the Carolina Panthers. Keep him out of your non-two-QB-league fantasy lineups until he shows some signs of life.
Derrick Henry - RB - Tennessee Titans
Tennessee Titans RB Derrick Henry saw 14 snaps in the first quarter in Week 1 versus the Miami Dolphins and only six more the rest of the way, good for only 30 percent of the team's 67 snaps. However, he was less disappointed over his playing time and more upset with performance. 'I felt like it was average, below average, and that's not how I want to play. I have to be better as a player. I definitely need to get it going personally. I need to play better this week, be effective in the running game, make plays, and help open everything else up,' Henry said.
Huddle Up: Henry finished the day with 10 carries for 26 yards, although it should be noted he had a 62-yard touchdown run wiped out by a penalty. There will be better days ahead, if only because every game won't have two weather delays and feature a negative game script. With that said, he's quickly shaping up as a volatile touchdown-dependent - if not game script dependent - RB2 for fantasy purposes.